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Chemical Structure : VU-29
CAS No.: 890764-36-0
Catalog No.: PC-62953Not For Human Use, Lab Use Only.
VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM).
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|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM).
VU-29 (DPAP) potentiates both DHPG-induced LTP and threshold θ-burst stimulation (TBS)-induced LTP in rat hippocampal slices.
| M.Wt | 384.395 | |
| Formula | C22H16N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide |
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1. Chen Y, et al. Mol Pharmacol. 2007 May;71(5):1389-98.
2. de Paulis T, et al. J Med Chem. 2006 Jun 1;49(11):3332-44.
3. Ayala JE, et al. Neuropsychopharmacology. 2009 Aug;34(9):2057-71.
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