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ZINC12427628

Chemical Structure : ZINC12427628

CAS No.: 937954-56-8

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ZINC12427628 (ZINC 12427628, Compound '628)

Catalog No.: PC-62819Not For Human Use, Lab Use Only.

ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM.
    ZINC12427628 enhances the binding of N-methyl scopolamine (NMS), while sparing the endogenous agonist acetylcholine, slows the dissociation rate of NMS from the M2 mAChR by 50-fold.
    The selective allostery between '628 and NMS was retained in membranes from adult rat hypothalamus and in neonatal rat cardiomyocytes.

    Physicochemical Properties

    M.Wt 448.501
    Formula C22H20N6O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-acetamidophenyl)-2-((4-allyl-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio)acetamide

    References

    1. Korczynska M, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428.

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