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Chemical Structure : ZINC12427628
Catalog No.: PC-62819Not For Human Use, Lab Use Only.
ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM.
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ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM.
ZINC12427628 enhances the binding of N-methyl scopolamine (NMS), while sparing the endogenous agonist acetylcholine, slows the dissociation rate of NMS from the M2 mAChR by 50-fold.
The selective allostery between '628 and NMS was retained in membranes from adult rat hypothalamus and in neonatal rat cardiomyocytes.
| M.Wt | 448.501 | |
| Formula | C22H20N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Korczynska M, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428.
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