Catalog No.: PC-62985Not For Human Use, Lab Use Only.
L-AP4 is a selective group III metabotropic glutamate receptor agonist with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
L-AP4 is a selective group III metabotropic glutamate receptor agonist with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
L-AP4 significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner.
L-AP4 significantly inhibits the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion.
Physicochemical Properties
M.Wt
183.1
Formula
C4H10NO5P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
L-(+)-2-Amino-4-phosphonobutyric acid
References
1. Evans RH, et al. Br J Pharmacol. 1982 Jan;75(1):65-75.
2. Bushell TJ, et al. Neuropharmacology. 1995 Feb;34(2):239-41.
3. Tones MA, et al. Neuroreport. 1995 Dec 29;7(1):117-20.
