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Chemical Structure : JNJ16567083
Catalog No.: PC-62958Not For Human Use, Lab Use Only.
JNJ16567083 (EMQMCM) is a potent and selective mGluR1 antagonist that shows neuroprotective effects in some hypoxia-ischemia models.
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JNJ16567083 (EMQMCM) is a potent and selective mGluR1 antagonist that shows neuroprotective effects in some hypoxia-ischemia models; inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus.
JNJ16567083 significantly inhibits cue-induced reinstatement of nicotine-seeking behavior, also prevents nicotine priming-induced reinstatement of nicotine-seeking behavior.
| M.Wt | 311.43 | |
| Formula | C20H25NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pietraszek M, et al. Eur J Pharmacol. 2005 May 2;514(1):25-34.
2. Gravius A, et al. Behav Pharmacol. 2005 Mar;16(2):113-21.
3. Dravolina OA, et al. Neuropharmacology. 2007 Feb;52(2):263-9.
4. Śmiałowska M, et al. Neurotox Res. 2012 May;21(4):379-92.
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