LSP1-2111 | group III mGluR agonist | Probechem Biochemicals

Chemical Structure : LSP1-2111

LSP1-2111 (group III mGluR agonist)

Catalog No.: PC-62982Not For Human Use, Lab Use Only.

LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.

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Biological Activity

LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.
LSP1-2111 displays 25-, and 30-fold preference over mGlu7 and mGlu8 receptors.
LSP1-2111 selectively inhibits striatopallidal GABAergic transmission with no effect at a synapse modulated solely by the mGlu7 and mGlu8 receptors.
LSP1-2111 counteracts haloperidol-induced catalepsy in experimental parkinson model.

Physicochemical Properties

M.Wt	364.247
Formula	C12H17N2O9P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-amino-4-{hydroxy[hydroxy(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl}butanoic acid

References

1. Cajina M, et al. ACS Med Chem Lett. 2013 Dec 12;5(2):119-23.

2. Wierońska JM, et al. Neuropharmacology. 2010 Dec;59(7-8):627-34.

3. Wierońska JM, et al. Psychopharmacology (Berl). 2013 Jun;227(4):711-25.

4. Beurrier C, et al. FASEB J. 2009 Oct;23(10):3619-28.