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Chemical Structure : LSP1-2111
Catalog No.: PC-62982Not For Human Use, Lab Use Only.
LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.
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LSP1-2111 is a potent, selective, and brain penetrant group III mGluRs agonist with EC50 of 2.2 and 1.7 uM for mGluR4 and mGluR6, respectively.
LSP1-2111 displays 25-, and 30-fold preference over mGlu7 and mGlu8 receptors.
LSP1-2111 selectively inhibits striatopallidal GABAergic transmission with no effect at a synapse modulated solely by the mGlu7 and mGlu8 receptors.
LSP1-2111 counteracts haloperidol-induced catalepsy in experimental parkinson model.
| M.Wt | 364.247 | |
| Formula | C12H17N2O9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cajina M, et al. ACS Med Chem Lett. 2013 Dec 12;5(2):119-23.
2. Wierońska JM, et al. Neuropharmacology. 2010 Dec;59(7-8):627-34.
3. Wierońska JM, et al. Psychopharmacology (Berl). 2013 Jun;227(4):711-25.
4. Beurrier C, et al. FASEB J. 2009 Oct;23(10):3619-28.
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