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CDPPB

Chemical Structure : CDPPB

CAS No.: 781652-57-1

CDPPB (CD-PPB)

Catalog No.: PC-62955Not For Human Use, Lab Use Only.

CDPPB is a potent, selective, brain penetrant positive allosteric modulator of mGlu5 receptor with EC50 of 10 nM and 20 nM for human and rat mGluR5, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CDPPB is a potent, selective, brain penetrant positive allosteric modulator of mGlu5 receptor with EC50 of 10 nM and 20 nM for human and rat mGluR5, respectively.
CDPPB reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.

Physicochemical Properties

M.Wt 364.408
Formula C23H16N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

References

1. Kinney GG, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):199-206.

2. Chen Y, et al. Mol Pharmacol. 2007 May;71(5):1389-98.

3. Lindsley CW, et al. J Med Chem. 2004 Nov 18;47(24):5825-8.

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