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LSP4-2022

Chemical Structure : LSP4-2022

CAS No.: 1413405-33-0

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LSP4-2022

Catalog No.: PC-62983Not For Human Use, Lab Use Only.

LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.
    LSP4-2022 displays >100-fold selectivity over mGlu7 and mGlu8 (IC50=11.6 and 29.2 uM), no activity at the group I and -II mGlu receptors (EC50>100 uM).
    LSP4-2022 inhibits neurotransmission in cerebellar slices from mice, and possesses antiparkinsonian properties in a haloperidol-induced catalepsy test.

    Physicochemical Properties

    M.Wt 347.26
    Formula C13H18NO8P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-2-amino-4-({[4-(carboxymethoxy)phenyl](hydroxy)methyl}(hydroxy)phosphoryl)butanoic acid

    References

    1. Goudet C, et al. FASEB J. 2012 Apr;26(4):1682-93.

    2. Vilar B, et al. J Neurosci. 2013 Nov 27;33(48):18951-65.

    3. Podkowa K, et al. Neuropharmacology. 2015 Oct;97:338-45.

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