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Chemical Structure : LSP4-2022
Catalog No.: PC-62983Not For Human Use, Lab Use Only.
LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.
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LSP4-2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.
LSP4-2022 displays >100-fold selectivity over mGlu7 and mGlu8 (IC50=11.6 and 29.2 uM), no activity at the group I and -II mGlu receptors (EC50>100 uM).
LSP4-2022 inhibits neurotransmission in cerebellar slices from mice, and possesses antiparkinsonian properties in a haloperidol-induced catalepsy test.
| M.Wt | 347.26 | |
| Formula | C13H18NO8P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goudet C, et al. FASEB J. 2012 Apr;26(4):1682-93.
2. Vilar B, et al. J Neurosci. 2013 Nov 27;33(48):18951-65.
3. Podkowa K, et al. Neuropharmacology. 2015 Oct;97:338-45.
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