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VU6027459

Chemical Structure : VU6027459

CAS No.: 2597355-49-0

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VU6027459 (VU 6027459)

Catalog No.: PC-49593Not For Human Use, Lab Use Only.

VU6046980 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7).

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10 mg $468 In stock
25 mg $798 In stock
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Purity & Documentation Purity: 99.4% (HPLC) Select Batch:

Biological Activity

VU6046980 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7).
VU6046980 is inactive (EC50 > 30 μM, >10 μM at mGlu8) at the other mGlu receptors.
VU6027459 displays CNS penetration in both mice (Kp = 2.74) and rats (Kp= 4.78), and is orally bioavailable in rats (%F = 69.5).

Physicochemical Properties

M.Wt 380.399
Formula C21H18F2N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-4-(4-(2-fluorophenyl)piperazin-1-yl)-8-methoxyquinoline-3-carbonitrile

References

1. Reed CW, et al. ACS Med Chem Lett. 2020 Aug 20;11(9):1773-1779.

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