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Chemical Structure : VU6027459
Catalog No.: PC-49593Not For Human Use, Lab Use Only.
VU6046980 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7).
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VU6046980 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7).
VU6046980 is inactive (EC50 > 30 μM, >10 μM at mGlu8) at the other mGlu receptors.
VU6027459 displays CNS penetration in both mice (Kp = 2.74) and rats (Kp= 4.78), and is orally bioavailable in rats (%F = 69.5).
| M.Wt | 380.399 | |
| Formula | C21H18F2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Reed CW, et al. ACS Med Chem Lett. 2020 Aug 20;11(9):1773-1779.
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