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Chemical Structure : CVN636
Catalog No.: PC-20614Not For Human Use, Lab Use Only.
CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively.
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CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively.
CVN636 displays no clear activity agaonist other mGluRs (mGluR2,6,8 cAMP, mGluR1,3,5 Gαqi5 calcium flux assays) at 10 uM.
CVN636 (0.3, 1, 3 mg/kg oral) reduced ethanol self-administration in msP rats of alcohol use disorder.
| M.Wt | 377.43 | |
| Formula | C19H20FNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dickson L, et al. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449.
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