(S)-8B1i-4

Chemical Structure : (S)-8B1i-4

Catalog No.: PC-28753Not For Human Use, Lab Use Only.

(S)-8B1i-4 is the active enantiomer of 8B1i-4, and potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 46 nM.

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Biological Activity

(S)-8B1i-4 is the active enantiomer of 8B1i-4, and potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 46 nM.

Physicochemical Properties

M.Wt	462.98
Formula	C26H27ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-chlorophenyl)-4-(4-(2-methylpiperidine-1-carbonyl)benzyl)-6,7-dihydropyrazolo[1,5-a]pyrimidin-5(4H)-one

References

1. Fang Z, et al. bioRxiv [Preprint]. 2026 Oct 21:2026.10.20.760253.

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(S)-8B1i-4

Biological Activity

Physicochemical Properties

References

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