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Chemical Structure : (S)-ABS01-113
Catalog No.: PC-49148Not For Human Use, Lab Use Only.
(S)-ABS01-113 is a potent, highly selective and efficacious dopamine D3 receptor (D3R) partial agonist with EC50 of 7.6 nM, binds with high affinity to D3R with Ki value of 0.84 nM, >1,000-fold selectivity over D2R.
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(S)-ABS01-113 is a potent, highly selective and efficacious dopamine D3 receptor (D3R) partial agonist with EC50 of 7.6 nM, binds with high affinity to D3R with Ki value of 0.84 nM, >1,000-fold selectivity over D2R.
(S)-ABS01-113 displays excellent oral bioavailability and high brain penetration.
Pretreatment with (S)-ABS01-113 attenuated heroin-enhanced hyperactivity, heroin self-administration, and (heroin + cue)-induced reinstatement of drug-seeking behavior in animal models of opioid use disorders (OUD).
| M.Wt | 456.990 | |
| Formula | C25H30ClFN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ewa Galaj, et al. Neuropsychopharmacology. 2022 Jul 25. doi: 10.1038/s41386-022-01379-1.
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