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(S)-ACE-OH

Chemical Structure : (S)-ACE-OH

CAS No.: 73644-43-6 (Rac)

(S)-ACE-OH

Catalog No.: PC-23383Not For Human Use, Lab Use Only.

(S)-ACE-OH is a metabolite of acepromazin, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

(S)-ACE-OH is a metabolite of acepromazin, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking.

Physicochemical Properties

M.Wt 328.47
Formula C19H24N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)ethan-1-ol

References

1. Panrui Lu, et al. Cell. 2024 Oct 30:S0092-8674(24)01197-8.

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