| Cat. No. |
Product Name |
Information |
| PC-21965 |
PT-179
CRBN ligand
|
PT-179 is a selective molecular glue and thalidomide derivative, binds CRBN with a Kd of 587 nM, does not induce degradation of known pomalidomide neosubstrates. |
| PC-20467 |
Lenalidomide
CRBN ligand
|
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. |
| PC-49083 |
Z0933M
Skp1 inhibitor
|
Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays. |
| PC-73229 |
EN219
RNF114 ligand
|
EN219 is a fully synthetic covalent ligand that targets RNF114, recruites the E3 ubiquitin ligase RNF114 for targeted protein degradation. |
| PC-38086 |
Mezigdomide
Cereblon modulator
|
Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity. |
| PC-38042 |
WUN29654
CRBN modulator
|
WUN29654 is a thalidomide analog and a CRBN modulator with IC50 of 3.5 uM and Ki of 0.98 uM for CRBN binding. |
| PC-61056 |
VH298
VHL E3 ubiquitin ligase inhibitor
|
VH 298 is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays. |
| PC-60125 |
CC-885
|
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |
| PC-60116 |
VH-032
|
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.. |
| PC-60115 |
VHL Ligand 3 (VH032-Boc)
|
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein and PROTAC technology. |
| PC-21644 |
DCAF1 ligand 2
DCAF1 E3 ligase binder
|
DCAF1 ligand 2 is a useful DCAF1 E3 ligase receptor binder for DCAF1-based PROTACs design. |
| PC-21643 |
DCAF1 ligand 1
DCAF1 E3 ligase binder
|
DCAF1 ligand 1 is a selective DCAF1 E3 ligase receptor binder with SPR KD value of 0.03 uM. |
