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Cat. No. Product Name CAS No. Information
PC-61056

VH 298

2097381-85-4 VH 298 is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays.
PC-38610

VL285

1448188-57-5 VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins, attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 (IC50=0.34 uM).
PC-38591

BTX306

2230747-62-1 BTX306 (BTX-306) is a novel protein homeostatic modulator, potently reduces levels of GSPT1, eRF1, CK1α, MCL-1, and c-MYC in myeloma cells, overcomes bortezomib and lenalidomide resistance.
PC-38389

Eragidomide

1860875-51-9 Eragidomide (CC-90009) is a first-in-class, GSPT1-selective cereblon E3 ligase modulator, selectively degrades GSPT1 (EC50=9 nM) resulting in acute AML apoptosis and elimination of disease-driving leukemia stem cells (LSCs).
PC-73229

EN219

380351-29-1 EN219 is a fully synthetic covalent ligand that targets RNF114, recruites the E3 ubiquitin ligase RNF114 for targeted protein degradation.
PC-73170

Lenalidomide-Br

2093387-36-9 Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase and recruitment of CRBN protein, can be used for PROTACs design.
PC-73169

SY2-062

2093536-12-8 SY2-062 is a thalidomide derivative and useful precursor for synthesis of thalidomide-based PROTAC degrader.

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