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Chemical Structure : EN106
Catalog No.: PC-38760Not For Human Use, Lab Use Only.
EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively.
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EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively.
| M.Wt | 280.708 | |
| Formula | C13H13ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nathaniel J. Henning, et al. J. Am. Chem. Soc. 2022, 144, 2, 701–708.
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