VL285 | VHL ligand | Probechem Biochemicals

Chemical Structure : VL285

CAS No.: 1448188-57-5

VL285 (VL 285)

Catalog No.: PC-38610Not For Human Use, Lab Use Only.

VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins, attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 (IC50=0.34 uM).

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$348	In stock
100 mg		Get quote

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Biological Activity

VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins, attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 (IC50=0.34 uM).

Physicochemical Properties

M.Wt	532.659
Formula	C29H32N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Buckley DL, et al. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

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VL285 (VL 285)

Biological Activity

Physicochemical Properties

References

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