| Cat. No. |
Product Name |
Information |
| PC-38086 |
Mezigdomide
Cereblon modulator
|
Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity. |
| PC-38042 |
WUN29654
CRBN modulator
|
WUN29654 is a thalidomide analog and a CRBN modulator with IC50 of 3.5 uM and Ki of 0.98 uM for CRBN binding. |
| PC-61056 |
VH298
VHL inhibitor
|
VH298 (VH-298) is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays. |
| PC-60116 |
VH032
VHL ligand
|
VH032 (VHL ligand 1, VH-032) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM. |
| PC-60115 |
VHL Ligand 3 (VH032-Boc)
VHL ligand
|
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein and PROTAC technology. |
| PC-60108 |
Thalidomide-O-COOH
CRBN ligand
|
Thalidomide-O-COOH (Cereblon ligand 3) is a Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein for PROTAC design. |
| PC-60101 |
Thalidomide-4-OH
CRBN ligand
|
Thalidomide-4-OH (Cereblon ligand 2) is a Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein for PROTAC design. |
| PC-42180 |
Avadomide
CRBN ligand
|
Avadomide (CC-122) is a small molecule that binds to cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in DLBCL and T cells in vitro and in vivo. |
| PC-42764 |
Pomalidomide
IKZF1 degrader
|
Pomalidomide (CC4047) is a potent IKZF1 degrader with DC50 of 6 nM and Dmax=86%, has no effect on IKZF2 protein levels up to 50 μM. |
| PC-25148 |
CYCA-117-70
DCAF1 ligand
|
CYCA-117-70 is a small molecule ligand for the DCAF1 WDR domain with binding KD of 70 uM. |
| PC-24931 |
RBBP7 ligand Ynamide S9 intermidate
RBBP7 ligand
|
RBBP7 ligand Ynamide S9 intermidate is a novel covalent, electrophilic warhead and ligand of retinoblastoma binding protein 7 (RBBP7) E3 ligase, facilitating the development of PROTAC degraders targeting a wide range of proteins, including CDK4, PDE5, PI3K, AKT, BCR-ABL, BRD4, EGFRL858R, and EGFRL858R/T790M/C797S. |
| PC-24929 |
RBBP7 ligand Ynamide YE-1
RBBP7 ligand
|
RBBP7 ligand Ynamide is a novel covalent, electrophilic warhead and ligand of retinoblastoma binding protein 7 (RBBP7) E3 ligase, facilitating the development of PROTAC degraders targeting a wide range of proteins, including CDK4, PDE5, PI3K, AKT, BCR-ABL, BRD4, EGFRL858R, and EGFRL858R/T790M/C797S. |
