| Cat. No. |
Product Name |
Information |
| PC-60116 |
VH032
VHL ligand
|
VH032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM. |
| PC-60115 |
VHL Ligand 3 (VH032-Boc)
VHL ligand
|
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein and PROTAC technology. |
| PC-42180 |
Avadomide
CRBN ligand
|
Avadomide (CC-122) is a small molecule that binds to cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in DLBCL and T cells in vitro and in vivo. |
| PC-23383 |
(S)-ACE-OH
TRIM21 molecular glue
|
(S)-ACE-OH is a metabolite of acepromazin, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking. |
| PC-22818 |
KDRLKZ-3
|
KDRLKZ-3 is a negative control compound of KDRLKZ-1 and KDRLKZ-2 without affinity for E3 ligase KLHDC2. |
| PC-22817 |
KDRLKZ-2
KLHDC2 ligand
|
KDRLKZ-2 is a small-molecule ligand targeting the E3 ligase KLHDC2 with SPR Kd of 0.095 uM, dosplaces the SelK peptide with IC50 of 0.068 uM as measured by alphaLISA. |
| PC-22816 |
KDRLKZ-1
KLHDC2 ligand
|
KDRLKZ-1 is a small-molecule ligand targeting the E3 ligase KLHDC2 with SPR Kd of 0.36 uM, dosplaces the SelK peptide with IC50 of 0.21 uM as measured by alphaLISA. |
| PC-22414 |
HL389
CRL4 DCAF11 ligand
|
HL389 is a molecular glue acting as recruitment moiety for CRL4 DCAF11 and could be used for developed alkenyl oxindole-based PROTAC molecules. |
| PC-21644 |
DCAF1 ligand 2
DCAF1 E3 ligase binder
|
DCAF1 ligand 2 is a useful DCAF1 E3 ligase receptor binder for DCAF1-based PROTACs design. |
| PC-21643 |
DCAF1 ligand 1
DCAF1 E3 ligase binder
|
DCAF1 ligand 1 is a selective DCAF1 E3 ligase receptor binder with SPR KD value of 0.03 uM. |
| PC-21634 |
Cbl-b inhibitor 3
Cbl-b inhibitor
|
Cbl-b inhibitor 3 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 5.5 nM in Cbl-b LCK Ub TR-FRET assays. |
| PC-21633 |
Cbl-b inhibitor 2
Cbl-b inhibitor
|
Cbl-b inhibitor 2 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b. |
