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Pomalidomide

Chemical Structure : Pomalidomide

CAS No.: 19171-19-8

Pomalidomide (CC-4047;CC4047;CC 4047)

Catalog No.: PC-42764Not For Human Use, Lab Use Only.

Pomalidomide (CC4047) is a potent IKZF1 degrader with DC50 of 6 nM and Dmax=86%, has no effect on IKZF2 protein levels up to 50 μM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pomalidomide (CC4047) is a potent IKZF1 degrader with DC50 of 6 nM and Dmax=86%, has no effect on IKZF2 protein levels up to 50 μM.
Pomalidomide is potent inhibitor of TNF-α production, inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs, upregulates interferon gamma, IL-2 and IL-10.

Physicochemical Properties

M.Wt 273.2441
Formula C13H11N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-

References

1. Muller GW, et al. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30.

2. Payvandi F, et al. Cell Immunol. 2004 Aug;230(2):81-8.

3. Galustian C, et al. Cancer Immunol Immunother. 2009 Jul;58(7):1033-45.

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