RBBP7 ligand Ynamide YE-1

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Chemical Structure : RBBP7 ligand Ynamide YE-1

Catalog No.: PC-24929Not For Human Use, Lab Use Only.

RBBP7 ligand Ynamide is a novel covalent, electrophilic warhead and ligand of retinoblastoma binding protein 7 (RBBP7) E3 ligase, facilitating the development of PROTAC degraders targeting a wide range of proteins, including CDK4, PDE5, PI3K, AKT, BCR-ABL, BRD4, EGFRL858R, and EGFRL858R/T790M/C797S.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RBBP7 ligand Ynamide YE-1 is a novel covalent, electrophilic warhead and ligand of retinoblastoma binding protein 7 (RBBP7) E3 ligase, facilitating the development of PROTAC degraders targeting a wide range of proteins, including CDK4, PDE5, PI3K, AKT, BCR-ABL, BRD4, EGFRL858R, and EGFRL858R/T790M/C797S.

Physicochemical Properties

M.Wt	219.26
Formula	C11H9NO2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, N,4-diethynyl-N-methyl-

References

1. Liu Y, et al. Angew Chem Int Ed Engl. 2025 Jul 2:e202508538.

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