| Cat. No. |
Product Name |
Information |
| PC-21965 |
PT-179
CRBN ligand
|
PT-179 is a selective molecular glue and thalidomide derivative, binds CRBN with a Kd of 587 nM, does not induce degradation of known pomalidomide neosubstrates. |
| PC-20467 |
Lenalidomide
CRBN ligand
|
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. |
| PC-49083 |
Z0933M
Skp1 inhibitor
|
Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays. |
| PC-38766 |
NJH-2-030
FEM1B E3 ligand
|
EN106 derivative 3 is a EN106 derivative used for PROTAC design, EN106 is a covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation. |
| PC-38760 |
EN106
FEM1B ligand
|
EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively. |
| PC-38610 |
VL285
VHL ligand
|
VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins, attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 (IC50=0.34 uM). |
| PC-38591 |
BTX306
Protein homeostatic modulator
|
BTX306 (BTX-306) is a novel protein homeostatic modulator, potently reduces levels of GSPT1, eRF1, CK1α, MCL-1, and c-MYC in myeloma cells, overcomes bortezomib and lenalidomide resistance. |
| PC-38389 |
Eragidomide
GSPT1 degrader
|
Eragidomide (CC-90009) is a first-in-class, GSPT1-selective cereblon E3 ligase modulator, selectively degrades GSPT1 (EC50=9 nM) resulting in acute AML apoptosis and elimination of disease-driving leukemia stem cells (LSCs). |
| PC-73229 |
EN219
RNF114 ligand
|
EN219 is a fully synthetic covalent ligand that targets RNF114, recruites the E3 ubiquitin ligase RNF114 for targeted protein degradation. |
| PC-38086 |
Mezigdomide
Cereblon modulator
|
Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity. |
| PC-38042 |
WUN29654
CRBN modulator
|
WUN29654 is a thalidomide analog and a CRBN modulator with IC50 of 3.5 uM and Ki of 0.98 uM for CRBN binding. |
| PC-61056 |
VH298
VHL E3 ubiquitin ligase inhibitor
|
VH 298 is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays. |
