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Mezigdomide

Chemical Structure : Mezigdomide

CAS No.: 2259648-80-9

Mezigdomide (CC92480, CC 92480)

Catalog No.: PC-38086Not For Human Use, Lab Use Only.

Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity.
CC-92480 selectively degrades IKZF1 and ZFP91 in TCL cells with greater potency than pomalidomide.
CC-92480 is highly active against multiple TCL subtypes and showed greater efficacy than pomalidomide across 4 in vivo TCL models.

Physicochemical Properties

M.Wt 567.621
Formula C32H30FN5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile

References

1. Hansen JD, et al. J Med Chem. 2020 Jul 9;63(13):6648-6676.

2. Wu W, et al. Blood. 2021 Dec 22:blood.2021014701.

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