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(S)-PBMC

Chemical Structure : (S)-PBMC

CAS No.: 1352138-54-5

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(S)-PBMC (PBMC)

Catalog No.: PC-60788Not For Human Use, Lab Use Only.

(S)-PBMC is a potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (S)-PBMC is a potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8).
    (S)-PBMC antagonizes in vitro activation of human and guinea-pig TRPM8 and reverses menthol and cold-induced facilitation of the micturition reflex at plasma concentrations consistent with in vitro potencies.

    Physicochemical Properties

    M.Wt 434.536
    Formula C26H30N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-phenylethyl (2-aminoethyl)(4-(benzyloxy)-3-methoxybenzyl)carbamate

    References

    1. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.

    2. Knowlton WM, et al. PLoS One. 2011;6(9):e25894.

    3. Sałat K, et al. Curr Med Chem. 2013;20(11):1409-36.

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