| Cat. No. |
Product Name |
Information |
| PC-28527 |
ML-SI1
TRPML inhibitor
|
ML-SI1 is a small molecule TRPL calcium channel inhibitor with IC50 of 15 uM for TRPML1. |
| PC-28516 |
14-deoxy-11,12-didehydroandrographolide
TRPV3 inhibitor
|
14-deoxy-11,12-didehydroandrographolide (DDA, DDHA) is an andrographolide metabolite within antiviral, antipyretic, immunostimulant and anticancer activities, potently inhibits cannabidiol (CBD)-evoked TRPV3 activation with IC50 of 7 nM, modulates the immune system by regulating chemokine signaling, Rap1 signaling, cytokine-cytokine receptor interaction, MAPK signaling, NF-kappa B signaling, RAS signaling, p53 signaling, HIF-1 signaling, and natural killer cell-mediated cytotoxicity. |
| PC-28514 |
GSK2820986A
TRPC3 inhibitor
|
GSK2820986A (GSK-986) is a highly potent, selective TRPC3 inhibitor with pIC50 values of 8.15 (IC50=7 nM, hTRPC3) and 8.7 (IC50=2 nM, rTRPC3), respectively in FLIPR assays. |
| PC-28398 |
TRPM7-IN-1
TRPM7 inhibitor
|
TRPM7-IN-1 (SUD) is a small molecule transient receptor potential melastatin 7 channel (TRPM7) inhibitor, inhibits the expression and function of TRPM7, possess anticancer properties in vivo and in vitro. |
| PC-28382 |
AMG2850
TRPM8 antagonist
|
AMG2850 is a potent and selective antagonists of TRPM8, potently inhibits menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8 with IC50 of 156 nM. |
| PC-28381 |
TC-I 2014
TRPM8 antagonist
|
TC-I 2014 is a potent, selective and orally active Transient receptor potential melastatin 8 (TRPM8) antagonist with IC50 of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat TRPM8 respectively. |
| PC-28018 |
TRPV2 activator AV2-1
TRPV2 agonist
|
TRPV2 activator AV2-1 is a potent, selective TRPV2 activator, activates mTRPV2 (EC50=13.6 μM), hTRPV2 (EC50=51.8 μM) and rat TRPV2 (rTRPV2; EC50=36.3 μM). |
| PC-28017 |
Probenecid
TRPV2 agonist
|
Probenecid is a potent and specific activator of transient receptor potential vanilloid 2 (TRPV2) channel with EC50 of 31.9 uM, shows no activity against TRPV1, TRPV3, TRPV4, TRPM8 and TRPA1 channels. |
| PC-28016 |
10-Shogaol
TRPV1 agonist, COX-2 inhibitor
|
10-Shogaol ([10]-Shogaol) is an active component of steamed ginger increases adrenaline secretion via the activation of TRPV1, also partially activates 5-HT1A receptor with Ki of 3-20 uM, also inhibits PMA-stimulated MDA-MB-231 cell invasion by reducing MMP-9 expression, also inhibits COX-2 with IC50 of 7.5 uM. |
| PC-27959 |
Zucapsaicin
TRPV1 agonist
|
Zucapsaicin (Civamide, (Z)-Capsaicin) is the cis isomer of Capsaicin and orally active TRPV1 agonist, has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee. |
| PC-27704 |
WR1-002
TRPML1 agonist
|
WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1. |
| PC-27645 |
KM-001
TRPV3 inhibitor
|
KM-001 is a potent, specific TRPV3 inhibitor/antagonist, suppresses 2-APB (50 μM)-induced Ca2+ influx in HEK-293 cells transiently transfected with hTRPV3 with IC50 of 0.26 μM. |
