| Cat. No. |
Product Name |
Information |
| PC-25977 |
TRPM8 inhibitor PBMC
TRPM8 antagonist
|
PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays. |
| PC-25774 |
Z3571
TRPC6 inhibitor
|
Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7. |
| PC-25552 |
TRPM2 inhibitor LC4
TRPM2 inhibitor
|
TRPM2 inhibitor LC4 is a potent and selective TRPM2 inhibitor with IC50 of 0.66 uM, reduces the infarct volume and oxidative-stress level in transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25551 |
TRPM2 inhibitor D10
TRPM2 inhibitor
|
TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25470 |
TRPA1 agonist NMTA
TRPA1 agonist
|
TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects. |
| PC-24843 |
D-3263 hydrochloride
TRPM8 agonist
|
D-3263 hydrochloride is a specific small molecule agonist of transient receptor potential cation channel subfamily M member 8 (TRPM8). |
| PC-24809 |
AP-18
TRPA1 inhibitor
|
AP-18 is a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with IC50 of 3.1 uM and 4.5 μM for human and mouse TRPA1 respectively. |
| PC-24729 |
CIM0216
TRPM3 agonist
|
CIM0216 is a potent, selective synthetic TRPM3 activator / agonist, evokes robust increases in intracellular Ca2+ concentration in HEK-TRPM3 cells with EC50 of 0.77 uM. |
| PC-23880 |
Englerin A
TRPC4/5 agonist
|
Englerin A is a selective inhibitor of renal cancer cell growth with GI50 of 1-87 nM, also is a potent agonist of TRPC ion channels containing TRPC4 and TRPC5 subunits. |
| PC-23622 |
LY3526318
TRPA1 antagonist
|
LY3526318 is a potent, selective, and orally bioavailable TRPA1 antagonist, inhibits human TRPA1 channel-mediated inward currents with IC50 of 13.5 nM. |
| PC-23549 |
TRPC3 antagonist 60a
TRPC3 inhibitor
|
TRPC3 antagonist 60a is a potent, selective TRPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities. |
| PC-22256 |
TRPM5 agonist 64
TRPM5 agonist
|
TRPM5 agonist 64 (CBTA) is a potent, selective TRPM5 agonist with pEC50 of 7.8 and 8.1 for mTRPM5 and hTRPM5, respectively. |
