| Cat. No. |
Product Name |
Information |
| PC-27644 |
Colivin
TRPV3 inhibitor
|
Colivin is a potent, selective and orally bioactive TRPV3 inhibitor/antagonist, suppresses hTRPV3 activity with IC50 of 0.23 uM in Fluorescence-based Ca2+ influx assays, inhibits hTRPV3 and mTRPV3 equally. |
| PC-27337 |
TRPV1 agonist MSP20
TRPV1 agonist
|
MSP20 is a potent, selective TRPV1 agonist with EC50 of 46 nM and Emax=78.24%, shows no agonist activity against TRPV3, TRPV4 and TRPM8 receptors. |
| PC-26845 |
JD03-02
TRPC1/5 inhibitor
|
JD03-02 is a potent, highly selective small-molecule inhibitor of TRPC1/5 heteromers with IC50 of 0.2 nM, exhibiting >10,000-fold selectivity for TRPC1/5 heteromers over TRPC5 homomers. |
| PC-26577 |
BHV-2100
TRPM3 antagonist
|
BHV-2100 (Ponometrep, BHV2100) is a selective, peripherally restricted TRPM3 antagonist, inhibits human, mouse, and rat TRPM3 with IC50 of 1-10 nM, shows >1000x selectivity vs related channels and no significant off-target liabilities. |
| PC-26421 |
JD02-174A
TRPM3 antagonist
|
JD02-174A is a highly potent, specific TRPM3 antagonist with IC50 of 0.46 nM in patch-clamp assays, shows significant analgesic efficacy. |
| PC-26388 |
Isosakuranetin
TRPM3 inhibitor
|
Isosakuranetin is a flavanone natural compound and potent specific inhibitor of TRPM3 with IC50 of 50 nM. |
| PC-25977 |
TRPM8 inhibitor PBMC
TRPM8 antagonist
|
PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays. |
| PC-25774 |
Z3571
TRPC6 inhibitor
|
Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7. |
| PC-25552 |
TRPM2-IN-LC4
TRPM2 inhibitor
|
TRPM2 inhibitor LC4 is a potent and selective TRPM2 inhibitor with IC50 of 0.66 uM. |
| PC-25551 |
TRPM2 inhibitor D10
TRPM2 inhibitor
|
TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25470 |
TRPA1 agonist NMTA
TRPA1 agonist
|
TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects. |
| PC-24843 |
D-3263 hydrochloride
TRPM8 agonist
|
D-3263 hydrochloride is a specific small molecule agonist of transient receptor potential cation channel subfamily M member 8 (TRPM8). |
