Catalog No.: PC-49684Not For Human Use, Lab Use Only.
JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM.
JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM.
JT010 is highly selective for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 (EC50 values >1 uM).
JT010 (10 nM) failed to stimulate calcium influx in the C621S mutant cells but induced calcium influx in the wild type cells.
JT010 could induce TRPA1-specific pain model. increased the intracellular calcium concentration and extracellular signal-regulated kinase 1/2 phosphorylation, and up-regulated alkaline phosphatase mRNA in human dental pulp cells.
Topical treatment of TRPA1 specific agonist JT010 increased UVB-induced skin pigmentation in guinea pigs.
