| Cat. No. |
Product Name |
Information |
| PC-23230 |
Plumbagin
TRPV2 inhibitor
|
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities, also is a potent TRPV2 negative allosteric modulator with IC50 of 0.85 μM, exhibiting >14-fold selectivity over TRPV1, TRPV3 and TRPV4. |
| PC-22981 |
Capsazepine
TRPV1 antagonist
|
Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM. |
| PC-22742 |
GSK3491943
TRPV4 inhibitor
|
GSK3491943 is a potent, selective TRPV4 inhibitor with IC50 of 3.2 nM (hTRPV4). |
| PC-22421 |
TRPV1 antagonist CX-3
TRPV1 antagonist
|
TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with IC50 of 26.2 nM, inhibits TRPV1 current with IC50 value of 9.71 uM in whole-cell patch-clamp assay. |
| PC-22256 |
TRPM5 agonist 64
TRPM5 agonist
|
TRPM5 agonist 64 is a potent, selective TRPM5 agonist with pEC50 of 7.8 and .1 for mTRPM5 and hTRPM5, respectively. |
| PC-22170 |
TRPV2 antagonist SET2
TRPV2 antagonist
|
SET2 is a potent, subtype-selective inhibitor of transient receptor potential vanilloid type 2 (TRPV2) with IC50 of 0.46 uM. |
| PC-22128 |
TH-1177
TRPV6 inhibitor
|
TH-1177 is a small molecule TRPV6 calcium channel inhibitor, effectively blocks calcium entry in LNCaP prostate cancer cells and demonstrates inhibitory effects on prostate cancer proliferation. |
| PC-22127 |
SOR-C13 TFA
TRPV6 inhibitor
|
SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity, selective TRPV6 calcium channel inhibitor with IC50 of 14 nM. |
| PC-22083 |
PCC0208057
TRPC6 inhibitor
|
PCC0208057 is a potent, selective TRPC6 channel inhibitor, inhibits TRPC6-mediated Ca2+ concentration increase with IC50 of 2.44 uM, binds directly to TRPC6. |
| PC-21344 |
M085
TRPC3/6/7 activator
|
M085 (TRPC3/6/7 activator 4o) is a potent and selective TRPC3/6/7 activator with EC50 of 4.66 uM, also activates hTRPC6 with EC50 of 3.8 uM. |
| PC-21342 |
Hyperforin Dicyclohexylammonium Salt
TRPC6 activator
|
Hyperforin Dicyclohexylammonium Salt is a small molecule activator of TRPC6, elevates intracellular Ca2+ concentrations by activating TRPC6 channels while not activating other TRPC isoforms. |
| PC-21131 |
AAL-149
TRPM7 inhibitor
|
AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo. |
