| Cat. No. |
Product Name |
Information |
| PC-23880 |
Englerin A
TRPC4/5 agonist
|
Englerin A is a selective inhibitor of renal cancer cell growth with GI50 of 1-87 nM, also is a potent agonist of TRPC ion channels containing TRPC4 and TRPC5 subunits. |
| PC-23871 |
Primidone
TRPM3 inhibitor
|
Primidone is an anticonvulsant agent and highly efficient, selective TRPM3 blocker IC50 of 0.6 uM and marked specificity for TRPM3. |
| PC-23865 |
ELP-004
TRPC inhibitor
|
ELP-004 is a small molecule inhibitor of transient receptor potential canonical (TRPC) channels, inhibits TRPC channel–mediated Ca2+ entry with high potency, preferentially inhibits inflammatory cytokine-induced pathological osteoclastogenesis. |
| PC-23765 |
Naltriben mesylate
TRPM7 agonist
|
Naltriben mesylate is a potent, selective delta-opioid receptor (DOR) antagonist with Ki of 0.013 nM, also is a potent TRPM7 agonist. |
| PC-23622 |
LY3526318
TRPA1 antagonist
|
LY3526318 is an orally bioavailable, potent, and selective TRPA1 antagonist with limited penetration to the central nervous system, effectively blocks cinnamaldehyde-evoked activation of rat and human TRPA1. |
| PC-23550 |
Pyr3
TRPC3 inhibitor
|
Pyr3 is a potent, selective inhibitor of transient receptor potential canonical channel 3 (TRPC3) with IC50 of 700 nM for inhibition of TRPC3-mediated Ca2+ influx. |
| PC-23549 |
TRPC3 antagonist 60a
TRPC3 inhibitor
|
TRPC3 antagonist 60a is a potent, selective RPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities. |
| PC-23230 |
Plumbagin
TRPV2 inhibitor
|
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities, also is a potent TRPV2 negative allosteric modulator with IC50 of 0.85 μM, exhibiting >14-fold selectivity over TRPV1, TRPV3 and TRPV4. |
| PC-22981 |
Capsazepine
TRPV1 antagonist
|
Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM. |
| PC-22742 |
GSK3491943
TRPV4 inhibitor
|
GSK3491943 is a potent, selective TRPV4 inhibitor with IC50 of 3.2 nM (hTRPV4). |
| PC-22421 |
TRPV1 antagonist CX-3
TRPV1 antagonist
|
TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with IC50 of 26.2 nM, inhibits TRPV1 current with IC50 value of 9.71 uM in whole-cell patch-clamp assay. |
| PC-22256 |
TRPM5 agonist 64
TRPM5 agonist
|
TRPM5 agonist 64 is a potent, selective TRPM5 agonist with pEC50 of 7.8 and .1 for mTRPM5 and hTRPM5, respectively. |
