| Cat. No. |
Product Name |
Information |
| PC-49276 |
CRCD2
NT5C2 inhibitor
|
CRCD2 is a first-in-class specific small molecule inhibitor of the cytosolic 5' nucleotidase II (NT5C2), directly binds to NT5C2 R367Q recombinant protein with KD of 70.9 uM, shows broadly activies against leukemias bearing highly prevalent relapse-associated mutant forms of NT5C2 in vitro and in vivo. |
| PC-47023 |
JNc-463
TRPV4-eNOS activator
|
JNc-463 is a small-molecule that could increase the TRPV4-eNOS interaction, enhances vasodilation and exert antihypertensive effects in mice. |
| PC-38676 |
Libvatrep
TRPV1 antagonist
|
Libvatrep (SAF312) is a potent, selective non-competitive inhibitor/antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), shows potential for treatment of ocular surface pain. |
| PC-38603 |
Mesendogen
TRPM6 inhibitor
|
Mesendogen (Compound 6528694, MEG) is a small molecule inhibitor of TRPM6 channel, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells (hESCs) through alteration of magnesium homeostasis. |
| PC-38390 |
Evifacotrep
TRPC5 inhibitor
|
Evifacotrep is a potent selective transient receptor potential channel 5 (TRPC5) antagonist. |
| PC-73430 |
Motugivatrep
TRPV1 antagonist
|
Motugivatrep is a potent, selective transient receptor potential vanilloid 1 (TRPV1) antagonist. |
| PC-73351 |
ZINC17988990
TRPV5 inhibitor
|
ZINC 17988990 is a potent, selective inhibitor of TRPV5 mediated currents, inhibits rbTRPV5/hTRPV5 with IC50 of 106/177 nM, showing marked selectivity for TRPV5 over TRPV6. |
| PC-73173 |
ML-SI3
TRPML inhibitor
|
ML-SI3 is a synthetic inhibitor of TRPML calcium channel blocker. |
| PC-73096 |
GSK3527497
TRPV4 inhibitor
|
GSK3527497 (GSK-3527497) is a potent, selective TRPV4 inhibitor with IC50 of 12 nM (hTRPV4). |
| PC-72354 |
RGM8-51
TRPM8 antagonist
|
RGM8-51 is a β-lactam derivative, potent, selective TRPM8 antagonist with IC50 of 1.06 and 1.74 uM for rat and human TRPM8, respectively. |
| PC-72122 |
tatM2NX
TRPM2 antagonist
|
tatM2NX is a novel potent, selective, cell permeable, peptide TRPM2 channel antagonist with IC50 of 396 nM, IC90 of 2 uM (TRPM2 channel currents), prevents ligand binding and TRPM2 activation. |
| PC-63429 |
JNJ-38893777 sulfate
|
JNJ-38893777 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain.. |
