| Cat. No. |
Product Name |
Information |
| PC-35234 |
TRPM4 inhibitor 5
TRPM4 inhibitor, TMEM206 inhibitor
|
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM. |
| PC-35045 |
DS88790512 hydrochloride
TRPC6 inhibitor
|
DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM). |
| PC-35044 |
DS88790512
TRPC6 inhibitor
|
DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM). |
| PC-63429 |
JNJ-38893777 sulfate
TRPV1 antagonist
|
JNJ-38893777 sulfate is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain. |
| PC-63428 |
JNJ-38893777
TRPV1 inhibitor
|
JNJ-38893777 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain. |
| PC-63414 |
JNJ-39729209
TRPV1 antagonist
|
JNJ-39729209 is a potent, selective TRPV1 antagonist with binding pKi of 7.8 and 7.9 for human and rat TRPV1, respectively. |
| PC-43289 |
ML204 hydrochloride
TRPC4/TRPC5 inhibitor
|
ML204 hydrochloride is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
| PC-43288 |
ML204
TRPC4/TRPC5 inhibitor
|
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
| PC-43222 |
Optovin
TRPA1 ligand
|
Optovin is a reversible photoactivated TRPA1 ligand that can be photoactivated by violet light, enables light-mediated neuronal excitation in treated animals with EC50 of 2 uM at 387 nm (violet), but not to 485 nm (blue), 560 nm (green) or longer wavelengths. |
| PC-43202 |
Asivatrep
TRPV1 inhibitor
|
Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1. |
| PC-43073 |
Pyr6
TRPC3 inhibitor
|
Pyr6 is a potent, selective inhibitor of TRPC3 channel with IC50 of 0.49 uM (thapsigargin-depleted native RBL-2H3 cells for SOCE). |
| PC-62914 |
JYL-1421
TRPV1 antagonist
|
JYL-1421 (SC-0030) is a potent, competitive TRPV1 receptor antagonist with Ki of 53.5 nM, antagonizes capsaicin-induced calcium uptake with EC50 of 9.2 nM. |
