| Cat. No. |
Product Name |
Information |
| PC-63414 |
JNJ-39729209
TRPV1 antagonist
|
JNJ-39729209 is a potent, selective TRPV1 antagonist with binding pKi of 7.8 and 7.9 for human and rat TRPV1, respectively. |
| PC-43289 |
ML204 hydrochloride
TRPC4/TRPC5 inhibitor
|
ML204 hydrochloride is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
| PC-43288 |
ML204
TRPC4/TRPC5 inhibitor
|
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
| PC-43222 |
Optovin
TRPA1 ligand
|
Optovin is a reversible photoactivated TRPA1 ligand that can be photoactivated by violet light, enables light-mediated neuronal excitation in treated animals with EC50 of 2 uM at 387 nm (violet), but not to 485 nm (blue), 560 nm (green) or longer wavelengths. |
| PC-43202 |
Asivatrep
TRPV1 inhibitor
|
Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1. |
| PC-43073 |
Pyr6
TRPC3 inhibitor
|
Pyr6 is a potent, selective inhibitor of TRPC3 channel with IC50 of 0.49 uM (thapsigargin-depleted native RBL-2H3 cells for SOCE). |
| PC-62914 |
JYL-1421
TRPV1 antagonist
|
JYL-1421 (SC-0030) is a potent, competitive TRPV1 receptor antagonist with Ki of 53.5 nM, antagonizes capsaicin-induced calcium uptake with EC50 of 9.2 nM. |
| PC-62628 |
GSK205 derivative 16-8
TRPV4/TRPA1 inhibitor
|
GSK205 derivative 16-8 is a specific small molecule dual-inhibitor of TRPV4 and TRPA1 with IC50 of 0.45 and 0.41 uM, respectively. |
| PC-62627 |
GSK205
TRPV4 inhibitor
|
GSK205 is a selective small molecule TRPV4 channel inhibitor with IC50 of 4.19 uM. |
| PC-62504 |
HC-070
TRPC4/TRPC5 inhibitor
|
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
| PC-62012 |
ADM 12
TRPA1 inhibitor, CA IX inhibitor
|
ADM 12 (ADM_12, ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay. |
| PC-61767 |
JNc-440
TRPV4-KCa2.3 enhancer
|
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3. |
