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ML2-SA1

Chemical Structure : ML2-SA1

CAS No.:

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ML2-SA1 (EVP-22)

Catalog No.: PC-72671Not For Human Use, Lab Use Only.

ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively.
    ML2-SA1 displays high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels.
    ML2-SA1 directly stimulates release of the chemokine CCL2 from macrophages, also stimulates macrophage migration, thus mimicking CCL2 function.

    Physicochemical Properties

    M.Wt 282.2
    Formula C14H13Cl2NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(2,6-Dichlorophenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene

    References

    1. Plesch E, et al. Elife. 2018 Nov 27;7:e39720.

    2. Santoni G, et al. Int J Mol Sci. 2022 Jan 8;23(2):688.

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