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Cat. No. Product Name Information
PC-23549

TRPC3 antagonist 60a

TRPC3 inhibitor

TRPC3 antagonist 60a is a potent, selective TRPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities.
PC-22128

TH-1177

TRPV6 inhibitor

TH-1177 is a small molecule TRPV6 calcium channel inhibitor, effectively blocks calcium entry in LNCaP prostate cancer cells and demonstrates inhibitory effects on prostate cancer proliferation.
PC-21908

GDC-6599

TRPA1 antagonist

Nedizantrep (GDC-6599) is a potent, selective transient receptor potential ankyrin 1 (TRPA1) antagonist with IC50 of 5.3 nM (hTRPA1), exhibits TRPA1 cell potency (IC50=20 nM) in the Ca2+ influx assay in CHO cells.
PC-21579

HC-030031

TRPA1 inhibitor

HC-030031 is a potent, selective TRPA1 inhibitor, inhibits AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.
PC-21344

M085

TRPC3/6/7 activator

M085 (TRPC3/6/7 activator 4o) is a potent and selective TRPC3/6/7 activator with EC50 of 4.66 uM, also activates hTRPC6 with EC50 of 3.8 uM.
PC-21130

VPC01091.4

TRPM7 inhibitor

VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.
PC-20875

TRPV2 inhibitor IV2-1

TRPV2 inhibitor

TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM.
PC-20743

SAR7334

TRPC6 inhibitor

SAR7334 (SAR-7334 ) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM.
PC-20552

GsMTx4

TRPC1/6 inhibitor

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs).
PC-20367

TRPM5 inhibitor NDNA

TRPM5 inhibitor

TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM.
PC-20366

Triphenylphosphine oxide

TRPM5 inhibitor

Triphenylphosphine oxide (TPPO) is a selective and potent inhibitor of TRPM5 with IC50 of 12 and 30 uM for human and murine TRPM5 heterologously expressed in HEK293 cells.
PC-49702

AZ465

TRPA1 inhibitor

AZ465 (AZ-465) is a potent selective TRPA1 inhibitor, potently inhibitor Zn2+ (100 μM)- and O-chlorobenzylidene malononitrile (CS) (10 nM)-induced TRPA1 activation with IC50 of 85 nM and 20 nM, respectively.

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