| Cat. No. |
Product Name |
Information |
| PC-26098 |
Vocacapsaicin hydrochloride
TRPV1 agonist
|
Vocacapsaicin hydrochloride (CA-008) is a non-opioid, water-soluble and injectable prodrug of capsaicin, a potent agonist of TRPV1 channel. |
| PC-25977 |
TRPM8 inhibitor PBMC
TRPM8 antagonist
|
PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays. |
| PC-25933 |
AV3-1
TRPV3 activator
|
AV3-1 (TRPV3 activator 1) is a specific small molecule TRPV3 activator with EC50 of 2.0 μM for mouse TRPV3 and 7.2 μM for human TRPV3. |
| PC-25855 |
Olvanil
TRPV1 agonist
|
Olvanil (NE-19550, N-Vanillyloleamide) is a potent, selective agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with EC50 of 0.7 nM. |
| PC-25854 |
Capsiate
TRPV1 agonist
|
Capsiate is a non-pungent capsaicin analog and potent, selective TRPA1 agonist, evokes inward currents at -60 mV in the HEK293 cells expressing TRPV1with EC50 of 290 nM. |
| PC-25781 |
PPZ2
TRPC3/C6/C7 activator
|
PPZ2 is a selective activator of TRPC3/TRPC6/TRPC7, activates DAG-activated TRPC3/TRPC6/TRPC7 channels, promotes neurite outgrowth and neuronal survival via downstream Ca2+-dependent signals. |
| PC-25780 |
L687
TRPC3/C6/C7 activator
|
L687 is a potent, specific TRPC3/C6/C7 activator, induces cellular antisense oligonucleotide (ASO) uptake, also induces dextran uptake and increases endocytosis. |
| PC-25774 |
Z3571
TRPC6 inhibitor
|
Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7. |
| PC-25552 |
TRPM2 inhibitor LC4
TRPM2 inhibitor
|
TRPM2 inhibitor LC4 is a potent and selective TRPM2 inhibitor with IC50 of 0.66 uM, reduces the infarct volume and oxidative-stress level in transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25551 |
TRPM2 inhibitor D10
TRPM2 inhibitor
|
TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25470 |
TRPA1 agonist NMTA
TRPA1 agonist
|
TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects. |
| PC-25400 |
Br-cis-22a
TRPV6 inhibitor
|
Br-cis-22a is a brominated PCHPD analog of TRPV6 inhibitor cis-22a, inhibits uptake of Cd2+ into hTRPV6-expressing HEK 293 cells with IC50 of 0.96 uM. |
