Catalog No.: PC-25854Not For Human Use, Lab Use Only.
Capsiate is a non-pungent capsaicin analog and potent, selective TRPA1 agonist, evokes inward currents at -60 mV in the HEK293 cells expressing TRPV1with EC50 of 290 nM.
Capsiate is a non-pungent capsaicin analog and potent, selective TRPV1 agonist, evokes inward currents at -60 mV in the HEK293 cells expressing TRPV1with EC50 of 290 nM. Capsiate is the main ingredient of "CH-19 Sweet" (Capsicum annuun L.) produced by selective breeding of red pepper. Capsiate suppresses T cell activation by inhibiting NF-κB-dependent transcriptional activity. Capsiate does activate the cloned capsaicin receptor TRPV1 with a similar potency as capsaicin. Subcutaneously-injected capsiate induces nociceptive responses in mice.
