| Cat. No. |
Product Name |
Information |
| PC-70135 |
Tranilast
TRPV2 inhibitor
|
Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. |
| PC-60294 |
GSK-2193874
|
GSK-2193874 (GSK2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively. |
| PC-70051 |
A-967079
|
A-967079 (A 967079) is a potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively. |
| PC-60025 |
AC1903
|
AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM. |
| PC-60019 |
2-APB
TRP channel inhibitor
|
2-APB (2-Aminoethoxydiphenylborane) is a membrane permeable IP3 receptor antagonist and broad TRP channels (TRPC5, TRPM2) blocker. |
| PC-45654 |
GSK-1016790A
TRPV4 agonist
|
GSK-1016790A is a potent TRPV4 channel agonist, induces Ca2+ influx in HEK cells expressing human TRPV4 with EC50 of 2.1 nM. |
| PC-42591 |
Capsaicin
TRPV1 agonist
|
Capsaicin is an active component of chili pepper, potent agonist of TRPV1 channel with EC50 of 0.29 uM. |
| PC-42799 |
Icilin
TRPM8 agonist
|
Icilin (AG-3-5) is asuper-cooling agent that fuctions as a potent TRPM8 agonist with EC50 of 0.2 uM. |
| PC-45093 |
Mavatrep
TRPV1 inhibitor
|
Mavatrep (JNJ-39439335) is a selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx). |
| PC-45772 |
RN-1734
TRPV4 inhibitor
|
RN-1734 (RN1734) is a potent, selective TRPV4 antagonist with IC50 of 2.3, 3.2 and 5.9 uM for hTRPV4, rTRPV4 and mTRPV4 channels, respectively. |
| PC-42688 |
SB-705498
TRPV1 antagonist
|
SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor). |
| PC-42419 |
AMG-9810
TRPV1 inhibitor
|
AMG-9810 is a potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, respectively. |
