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SH045

Chemical Structure : SH045

CAS No.: 2230050-13-0

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SH045 (SH-045, Larixyl-6-N-methylcarbamate)

Catalog No.: PC-72566Not For Human Use, Lab Use Only.

SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM.
    SH045 displays 13-fold subtype selectivity over TRPC3 in stably expressing HEK293 cells.
    Treatment of isolated perfused lung preparations with SH045 led to a decrease in lung ischemia-reperfusion edema (LIRE), a life-threatening condition associated with TRPC6 that may occur after organ transplantation.

    Physicochemical Properties

    M.Wt 363.53
    Formula C22H37NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Larixyl-6-N-methylcarbamate

    References

    1. Stephanie Häfner, et al. ChemMedChem. 2018 May 23;13(10):1028-1035.

    2. Zheng Z, et al. Sci Rep. 2022 Feb 22;12(1):3038.

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