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Chemical Structure : SH045
Catalog No.: PC-72566Not For Human Use, Lab Use Only.
SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM.
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SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM.
SH045 displays 13-fold subtype selectivity over TRPC3 in stably expressing HEK293 cells.
Treatment of isolated perfused lung preparations with SH045 led to a decrease in lung ischemia-reperfusion edema (LIRE), a life-threatening condition associated with TRPC6 that may occur after organ transplantation.
| M.Wt | 363.53 | |
| Formula | C22H37NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stephanie Häfner, et al. ChemMedChem. 2018 May 23;13(10):1028-1035.
2. Zheng Z, et al. Sci Rep. 2022 Feb 22;12(1):3038.
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