| Cat. No. |
Product Name |
Information |
| PC-21131 |
AAL-149
TRPM7 inhibitor
|
AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo. |
| PC-21060 |
MK6-83
TRPML1 agonist
|
MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM. |
| PC-20875 |
TRPV2 inhibitor IV2-1
TRPV2 inhibitor
|
TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM. |
| PC-20367 |
TRPM5 inhibitor NDNA
TRPM5 inhibitor
|
TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM. |
| PC-20366 |
Triphenylphosphine oxide
TRPM5 inhibitor
|
Triphenylphosphine oxide (TPPO) is a selective and potent inhibitor of TRPM5 with IC50 of 12 and 30 uM for human and murine TRPM5 heterologously expressed in HEK293 cells. |
| PC-49702 |
AZ465
TRPA1 inhibitor
|
AZ465 (AZ-465) is a potent selective TRPA1 inhibitor, potently inhibitor Zn2+ (100 μM)- and O-chlorobenzylidene malononitrile (CS) (10 nM)-induced TRPA1 activation with IC50 of 85 nM and 20 nM, respectively. |
| PC-49701 |
AMG2504
TRPA1 inhibitor
|
AMG2504 (AMG 2504) is a selective small molecule TRPA1 inhibitor, inhibits AITC-induced increase in intracellular calcium mediated by TRPA1 in CHO cells with IC50 of 35 nM. |
| PC-49700 |
GRC-17536
TRPA1 inhibitor
|
GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays. |
| PC-49696 |
BAY-390
TRPA1 inhibitor
|
BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively. |
| PC-49684 |
JT010
TRPA1 agonist
|
JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM. |
| PC-49443 |
AMG21629
TRPV1 antagonist
|
AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively. |
| PC-49276 |
CRCD2
NT5C2 inhibitor
|
CRCD2 is a first-in-class specific small molecule inhibitor of the cytosolic 5' nucleotidase II (NT5C2), directly binds to NT5C2 R367Q recombinant protein with KD of 70.9 uM, shows broadly activies against leukemias bearing highly prevalent relapse-associated mutant forms of NT5C2 in vitro and in vivo. |
