| Cat. No. |
Product Name |
Information |
| PC-62628 |
GSK205 derivative 16-8
TRPV4/TRPA1 inhibitor
|
GSK205 derivative 16-8 is a specific small molecule dual-inhibitor of TRPV4 and TRPA1 with IC50 of 0.45 and 0.41 uM, respectively. |
| PC-62627 |
GSK205
TRPV4 inhibitor
|
GSK205 is a selective small molecule TRPV4 channel inhibitor with IC50 of 4.19 uM. |
| PC-62504 |
HC-070
TRPC4/TRPC5 inhibitor
|
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
| PC-62012 |
ADM 12
TRPA1 inhibitor, CA IX inhibitor
|
ADM 12 (ADM_12, ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay. |
| PC-61767 |
JNc-440
TRPV4-KCa2.3 enhancer
|
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3. |
| PC-61534 |
V116517
TRPV1 inhibitor
|
V116517 is a potent, selective, oral bioavailable TRPV1 antagonist with IC50 of 35.1 nM. |
| PC-61533 |
ABT-102
TRPV1 antagonist
|
ABT-102 is a potent, highly selective, orally active TRPV1 antagonist that inhibits agonist-evoked increases in intracellular Ca(2+) levels with IC50 of 5-7 nM. |
| PC-61374 |
Elismetrep
TRPM8 antagonist
|
Elismetrep (MT-8554) is a novel specific TRPM8 channel antagonist for treatment or prevention vasomotor symptoms. |
| PC-70337 |
GSK 2833503A
TRPC3/6 inhibitor
|
GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively. |
| PC-70336 |
GSK 2332255B
TRPC3/6 inhibitor
|
GSK 2332255B (GSK2332255B, GSK255B) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively. |
| PC-61156 |
ASP7663
TRPA1 agonist
|
ASP7663 is a potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively. |
| PC-61124 |
AM-0902
TRPA1 inhibitor
|
AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM). |
