| Cat. No. |
Product Name |
Information |
| PC-60786 |
WS-12
TRPM8 agonist
|
WS-12 (Acoltremon, AR-15512, AVX-012) is a potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent. |
| PC-60785 |
PF-05105679
TRPM8 antagonist
|
PF-05105679 is a potent, selective TRPM8 channel inhibitor with IC50 of 103 nM (human TRPM8 currents inhibition). |
| PC-60742 |
DFL 23448
TRPM8 antagonist
|
DFL 23448 is a potent, selective TRPM8 channel antagonist with IC50 of 10 nM and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold. |
| PC-60720 |
DD-01050
TRPV1 antagonist
|
DD-01050 is a potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity. |
| PC-60719 |
JNJ 41876666
TRPM8 antagonist
|
JNJ 41876666 (JNJ-41876666) is a potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM. |
| PC-60718 |
AMTB hydrochloride
TRPM8 antagonist
|
AMTB hydrochloride is a selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6). |
| PC-60668 |
MRS 1477
TRPV1 agonist
|
MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM). |
| PC-60610 |
Larixyl acetate
TRPC6 blocker
|
Larixyl acetate is a potent, selective TRPC6 channel inhibitor with IC50 of 0.1-0.6 uM, 12- and 5-fold selectivity over related TRPC3 and TRPC7. |
| PC-70135 |
Tranilast
TRPV2 inhibitor
|
Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. |
| PC-60294 |
GSK-2193874
TRPV4 inhibitor
|
GSK-2193874 (GSK2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively. |
| PC-70051 |
A-967079
TRPA1 inhibitor
|
A-967079 (A 967079) is a potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively. |
| PC-70040 |
RN-9893 hydrochloride
TRPV4 inhibitor
|
RN-9893 hydrochloride is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively. |
