| Cat. No. |
Product Name |
Information |
| PC-28517 |
Carvacrol
TRPV3 agonist
|
Carvacrol (Cymophenol) is a small molecule agonist / activator of TRPV3 with EC50 of 0.39 uM, also is an inhibitor of Drosophila TRPL and mammalian TRPM7 channels, also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1 and induces apoptosis, shows antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. |
| PC-28515 |
SAR7334 hydrochloride
TRPC6 inhibitor
|
SAR7334 hydrochloride (SAR-7334) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM. |
| PC-28400 |
MRTF-A-IN-2
MRTF/SRF inhibitor, TRPM7-RhoA inhibitor
|
MRTF-A-IN-2 is a potent inhibitor of TRPM7-RhoA interaction, reduces reduced expression of the MRTF/SRF target genes TGF-β1 and TSPAN5, inhibiting cell proliferation and inducing senescence in HCC cells. |
| PC-28399 |
MRTF-A-IN-1
MRTF/SRF inhibitor, TRPM7-RhoA inhibitor
|
MRTF-A-IN-1 is a potent inhibitor of TRPM7-RhoA interaction, reduces reduced expression of the MRTF/SRF target genes TGF-β1 and TSPAN5, inhibiting cell proliferation and inducing senescence in HCC cells. |
| PC-28383 |
TRPM8 antagonist Compound 496
TRPM8 antagonist
|
TRPM8 antagonist Compound 496 is a potent and selective antagonists of TRPM8, potently inhibits menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8 with IC50 of 25.8 nM. |
| PC-28233 |
Ethylisopropylamiloride
Macropinocytosis inhibitor
|
Ethylisopropylamiloride (EIPA) is specific macropinocytosis inhibitor that inhibits endocytosis via the macropinocytic pathway, also inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 10.5 uM, inhibits epithelial sodium channels (ENaC) as well as of several other Na+/H+ antiporters. |
| PC-27302 |
TRPV4 antagonist 39
TRPV4 antagonist
|
TRPV4 antagonist 39 is a potent, selective TRPV4 antagonist with IC50 of 0.2 nM. |
| PC-27188 |
9-phenanthrol
TRPM4 inhibitor
|
9-Phenanthrol (9-Hydroxyphenanthrene) is a specific, reversible small molecule TRPM4 inhibitor with IC50 of 17 uM, is ineffective on the related channel TRPM5. |
| PC-26841 |
Ononetin
TRPM3 antagonist
|
Ononetin is a deoxybenzoin from Ononis spinosa and selective TRPM3 antagonist with IC50 of 0.3 uM. |
| PC-26530 |
CMP233
TRPM4 antagonist
|
CMP233 is a potent, selective TRPM4 channel antagonist with IC50 of 0.15 uM. |
| PC-26527 |
TRPM4 inhibitor PBA
TRPM4 inhibitor
|
TRPM4 inhibitor PBA is a specific small molecule inhibitor of Ca2+-activated monovalent cation channel TRPM4 with IC50 of 339 nM using the fluorescence-based Na+-influx assay on HEK293 cells stably overexpressing hTRPM4. |
| PC-26459 |
IMTU
TRPV1 antagonist
|
IMTU is a potent and selective TRPV1 antagonist with IC50 of 128.34 nM, significantly inhibits the capsaicin-induced calcium influx. |
