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Ethylisopropylamiloride

Chemical Structure : Ethylisopropylamiloride

CAS No.: 1154-25-2

Ethylisopropylamiloride (EIPA, L593754, MH 12-43)

Catalog No.: PC-28233Not For Human Use, Lab Use Only.

Ethylisopropylamiloride (EIPA) is specific macropinocytosis inhibitor that inhibits endocytosis via the macropinocytic pathway, also inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 10.5 uM, inhibits epithelial sodium channels (ENaC) as well as of several other Na+/H+ antiporters.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ethylisopropylamiloride (EIPA) is specific macropinocytosis inhibitor that inhibits endocytosis via the macropinocytic pathway, also inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 10.5 uM, inhibits epithelial sodium channels (ENaC) as well as of several other Na+/H+ antiporters.

Physicochemical Properties

M.Wt 299.76
Formula C11H18ClN7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Amino-N-carbamimidoyl-6-chloro-5-(ethyl(isopropyl)amino)pyrazine-2-carboxamide

References

1. Nakase I, et al. Mol Ther. 2004 Dec;10(6):1011-22.

2. Dai XQ, et al. Mol Pharmacol. 2007 Dec;72(6):1576-85.

3. Mercer J, et al. Nat Cell Biol. 2009;11:510–520.

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