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Cat. No. Product Name Information
PC-45093

Mavatrep

TRPV1 inhibitor

Mavatrep (JNJ-39439335) is a selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).
PC-45772

RN-1734

TRPV4 inhibitor

RN-1734 (RN1734) is a potent, selective TRPV4 antagonist with IC50 of 2.3, 3.2 and 5.9 uM for hTRPV4, rTRPV4 and mTRPV4 channels, respectively.
PC-42062

JNJ-17203212

TRPV1 antagonist

JNJ-17203212 is a potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.
PC-42688

SB-705498

TRPV1 antagonist

SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
PC-42419

AMG-9810

TRPV1 inhibitor

AMG-9810 is a potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, respectively.
PC-45556

PF-4840154

TRPA1 agonist

PF-4840154 is a potent, selective agonist of the rat (EC50=97 nM) and human (EC50=23 nM) TRPA1 channel.
PC-42017

SKF-96365 hydrochloride

SOCE inhibitor

SKF-96365 hydrochloride (SKF96365) is potent inhibitor of receptor-mediated calcium entry (RMCE) with IC50 of 8.5 and 11.7 uM for inhibition in platelets stimulated with ADP and thrombin, respectively.
PC-42689

AMG517

TRPV1 antagonist

AMG517 is a potent and selective vanilloid receptor TRPV1 antagonist with IC50 of 0.76 nM for hTRPV
PC-42931

SB-366791

TRPV1 antagonist

SB-366791 (SB366791) is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7 nM.
PC-42084

HC-067047

TRPV4 inhibitor

HC-067047 (HC067047) is a potent and selective TRPV4 antagonist with IC50 of 48 nM, 133 nM, and 17 nM for human, rat, and mouse TRPV4 in cell assays, respectively.
PC-45632

Pyr10

TRPC3 inhibitor

Pyr10 is a novel TRPC3-selective inhibitor, inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with IC50 of 0.72 uM.
PC-45764

BCTC

TRPV1 antagonist

BCTC is a highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.

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