Catalog No.: PC-42062Not For Human Use, Lab Use Only.
JNJ-17203212 is a potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.
JNJ-17203212 is a potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.
JNJ-17203212 exhibits high selectivity against a panel of receptors and transporters, and does not inhibits related TRP channels TRPV2, TRPV4, or TRPA1.
JNJ-17203212 inhibits both pH (pIC50=7.23) and capsaicin (pIC50=6.32)-induced channel activation.
JNJ-17203212 attenuates capsaicin evoked coughs, prevents core hypothermia evoked by capsaicin in vivo.
