Catalog No.: PC-45789Not For Human Use, Lab Use Only.
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
Clemizole is an H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
Clemizole also selectively and efficiently blocks TRPC5 currents and Ca(2+) entry with IC50 of 1-1.3 uM, 6-fold selectivity over TRPC4β (IC50 = 6.4 µM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1 uM) and TRPC6 (IC50=11.3 uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels.
