| Cat. No. |
Product Name |
Information |
| PC-43288 |
ML204
TRPC4/TRPC5 inhibitor
|
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
| PC-43202 |
Asivatrep
TRPV1 inhibitor
|
Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1. |
| PC-62914 |
JYL-1421
TRPV1 antagonist
|
JYL-1421 (SC-0030) is a potent, competitive TRPV1 receptor antagonist with Ki of 53.5 nM, antagonizes capsaicin-induced calcium uptake with EC50 of 9.2 nM. |
| PC-62504 |
HC-070
TRPC4/TRPC5 inhibitor
|
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
| PC-70337 |
GSK 2833503A
TRPC3/6 inhibitor
|
GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively. |
| PC-70336 |
GSK 2332255B
TRPC3/6 inhibitor
|
GSK 2332255B (GSK2332255B, GSK255B) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively. |
| PC-61124 |
AM-0902
|
AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM). |
| PC-60846 |
Pico145
TRPC1/4/5 inhibitor
|
Pico145 is a highly potent, subtype-selective TRPC1/4/5 channels inhibitor with potency ranged from 9 to 1300 pM, depending on the TRPC1/4/5 subtype and activation mechanism. |
| PC-60787 |
RQ-00203078
|
A potent, selective and orally available TRPM8 channel inhibitor with IC50 of 8.3 nM (hTRPM8). |
| PC-60785 |
PF-05105679
|
PF-05105679 is a potent, selective TRPM8 channel inhibitor with IC50 of 103 nM (human TRPM8 currents inhibition). |
| PC-60720 |
DD-01050
TRPV1 antagonist
|
DD-01050 is a potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity. |
| PC-60610 |
Larixyl acetate
TRPC6 blocker
|
Larixyl acetate is a potent, selective TRPC6 channel inhibitor with IC50 of 0.1-0.6 uM, 12- and 5-fold selectivity over related TRPC3 and TRPC7. |
