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Mavatrep

Chemical Structure : Mavatrep

CAS No.: 956274-94-5

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Mavatrep (JNJ-39439335, JNJ 39439335)

Catalog No.: PC-45093Not For Human Use, Lab Use Only.

Mavatrep (JNJ-39439335) is a selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).

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25 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mavatrep (JNJ-39439335) is a  selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).
Mavatrep (JNJ-39439335) exhibits potent in vitro functional activity and robust oral efficacy in multiple models of inflammatory pain.

Physicochemical Properties

M.Wt 422.4423
Formula C25H21F3N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-

References

1. Parsons WH, et al. J Med Chem. 2015 May 14;58(9):3859-74.

2. Mayorga AJ, et al. Scand J Pain. 2017 Aug 24;17:134-143.

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