Catalog No.: PC-42688Not For Human Use, Lab Use Only.
SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
SB-705498 causes rapid and reversible inhibition of the capsaicin (IC50=3 nM), acid (pH 5.3), or heat (50 degrees C; IC50=6 nM)-mediated activation of human TRPV1 (at -70 mV).
