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MRTF-A-IN-2

Chemical Structure : MRTF-A-IN-2

CAS No.:

MRTF-A-IN-2

Catalog No.: PC-28400Not For Human Use, Lab Use Only.

MRTF-A-IN-2 is a potent inhibitor of TRPM7-RhoA interaction, reduces reduced expression of the MRTF/SRF target genes TGF-β1 and TSPAN5, inhibiting cell proliferation and inducing senescence in HCC cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MRTF-A-IN-2 is a potent inhibitor of TRPM7-RhoA interaction, reduces reduced expression of the MRTF/SRF target genes TGF-β1 and TSPAN5, inhibiting cell proliferation and inducing senescence in HCC cells.

Physicochemical Properties

M.Wt 303.34
Formula C19H14FN3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3'-fluoro-[1,1'-biphenyl]-3-yl)-1H-benzo[d]imidazol-2-amine

References

1. Franz MJ, et al. Mol Ther Oncol. 2024 Aug 6;32(3):200855.

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