TRPM8 antagonist Compound 496

Chemical Structure : TRPM8 antagonist Compound 496

Catalog No.: PC-28383Not For Human Use, Lab Use Only.

TRPM8 antagonist Compound 496 is a potent and selective antagonists of TRPM8, potently inhibits menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8 with IC50 of 25.8 nM.

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Biological Activity

Physicochemical Properties

M.Wt	521.53
Formula	C24H18F3NO5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-(3-methylbenzo[b]thiophen-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

References

1. Gavva NR, et al. Mol Pain. 2012 May 9;8:36.

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TRPM8 antagonist Compound 496

Biological Activity

Physicochemical Properties

References

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