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JW-65

Chemical Structure : JW-65

CAS No.: 2763378-71-6

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JW-65 (JW65)

Catalog No.: PC-72922Not For Human Use, Lab Use Only.

JW-65 (JW65) is a selective, potent, CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JW-65 (JW65) is a selective, potent,CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3.
    JW-65 shows similar potency and selectivity on TRPC3 channels, but is metabolically much more stable than its precursor, demonstrated by its much longer half-life (>4 h) in mouse, rat, and human liver microsomes when compared to Pyr3.
    JW-65-treated mice showed substantially decreased susceptibility to PTZ-induced seizures in a dose-dependent manner.

    Physicochemical Properties

    M.Wt 445.223
    Formula C18H13Cl2F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1H-Pyrazole-4-carboxamide, 1-[4-(3,4-dichloro-2-oxo-1(2H)-pyridinyl)phenyl]-N-ethyl-5-(trifluoromethyl)-

    References

    1. Marwa M Nagib, et al. Epilepsia. 2022 Feb 18. doi: 10.1111/epi.17190.

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