Chemical Structure : GSK2798745
CAS No.:
1419609-94-1
GSK2798745
(GSK-2798745)
Catalog No. : PC-72599Not For Human Use, Lab Use Only.
GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7259901
Biological Activity
GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4).
Physicochemical Properties
M.Wt
460.538
Formula
C25H28N6O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(((5S,7S)-3-(5-(2-Hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile
References
1. Brooks CA, et al. ACS Med Chem Lett.
2. Ludbrook VJ, et al. ERJ Open Res.
3. Xu X, et al. J Pharmacol Exp Ther.
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