Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-TRP Channel-TRPM8 inhibitor PBMC
TRPM8 inhibitor PBMC

Chemical Structure : TRPM8 inhibitor PBMC

CAS No.: 925978-92-3

Add to Favorites

TRPM8 inhibitor PBMC

Catalog No.: PC-25977Not For Human Use, Lab Use Only.

PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays.
    PBMC shows selective inhibition of heterologously expressed TRPM8 over TRPV1 and TRPA1.
    PBMC shifts the voltage-dependence of TRPM8 channels.
    PBMC affects body temperature in a dose-dependent manner in mice.
    PBMC reduces acute cold-evoked behavioral responses. PBMC reduces cold hypersensitivity in CFA and CCI but not oxaliplatin pain models.

    Physicochemical Properties

    M.Wt 434.54
    Formula C26H30N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-phenylethyl-4-(benzyloxy)-3-methoxybenzyl(2-aminoethyl)carbamate

    References

    1. Knowlton WM, et al. PLoS One. 2011;6(9):e25894.

    2. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: