TRPM8 inhibitor PBMC

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Chemical Structure : TRPM8 inhibitor PBMC

Catalog No.: PC-25977Not For Human Use, Lab Use Only.

PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays.
PBMC shows selective inhibition of heterologously expressed TRPM8 over TRPV1 and TRPA1.
PBMC shifts the voltage-dependence of TRPM8 channels.
PBMC affects body temperature in a dose-dependent manner in mice.
PBMC reduces acute cold-evoked behavioral responses. PBMC reduces cold hypersensitivity in CFA and CCI but not oxaliplatin pain models.

Physicochemical Properties

M.Wt	434.54
Formula	C26H30N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-phenylethyl-4-(benzyloxy)-3-methoxybenzyl(2-aminoethyl)carbamate

References

1. Knowlton WM, et al. PLoS One. 2011;6(9):e25894.

2. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.

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