TRPC3 antagonist 60a is a potent, selective TRPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities.
TRPC3 antagonist 60a has 4-fold increased potency compared with that of JW-65.
TRPC3 antagonist 60a has no detectable inhibition on TRPC3-related ion channels (TRPC6, TRPC7, TRPA1, TRPV1, and TRPM8), especially its structurally close homologs TRPC6/7.
TRPC3 antagonist 60a corrects neuronal dysfunction induced by β-amyloid in vitro β-amyloidosis model.
TRPC3 antagonist 60a also mitigates 7PA2-induced overactivation of microglia and astrocytes, and corrects the loss of neuroprotective proteins (e.g., Syn I and PSD95) in the 7PA2-treated cells.
