Chemical Structure : TRPC3 antagonist 60a
Catalog No.: PC-23549Not For Human Use, Lab Use Only.
TRPC3 antagonist 60a is a potent, selective RPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities.
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TRPC3 antagonist 60a is a potent, selective RPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities.
TRPC3 antagonist 60a has 4-fold increased potency compared with that of JW-65.
TRPC3 antagonist 60a has no detectable inhibition on TRPC3-related ion channels (TRPC6, TRPC7, TRPA1, TRPV1, and TRPM8), especially its structurally close homologs TRPC6/7.
TRPC3 antagonist 60a corrects neuronal dysfunction induced by β-amyloid in vitro β-amyloidosis model.
TRPC3 antagonist 60a also mitigates 7PA2-induced overactivation of microglia and astrocytes, and corrects the loss of neuroprotective proteins (e.g., Syn I and PSD95) in the 7PA2-treated cells.
M.Wt | 431.24 | |
Formula | C18H15Cl2F3N4O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Wang J, et al. Bioorg Med Chem. 2024 Nov 26;117:118021.
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