Chemical Structure : TRPC3 antagonist 60a
CAS No.:
2767260-24-0
TRPC3 antagonist 60a
Catalog No.: PC-23549Not For Human Use, Lab Use Only.
TRPC3 antagonist 60a is a potent, selective RPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TRPC3 antagonist 60a is a potent, selective RPC3 antagonist with IC50 of 60 nM, has significant neuronal protective abilities.
TRPC3 antagonist 60a has 4-fold increased potency compared with that of JW-65.
TRPC3 antagonist 60a has no detectable inhibition on TRPC3-related ion channels (TRPC6, TRPC7, TRPA1, TRPV1, and TRPM8), especially its structurally close homologs TRPC6/7.
TRPC3 antagonist 60a corrects neuronal dysfunction induced by β-amyloid in vitro β-amyloidosis model.
TRPC3 antagonist 60a also mitigates 7PA2-induced overactivation of microglia and astrocytes, and corrects the loss of neuroprotective proteins (e.g., Syn I and PSD95) in the 7PA2-treated cells.
Physicochemical Properties
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M.Wt
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431.24
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Formula
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C18H15Cl2F3N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3,4-dichloro-1-(4-(4-((ethylamino)methyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pyridin-2(1H)-one
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References
1. Wang J, et al. Bioorg Med Chem. 2024 Nov 26;117:118021.
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