LY3526318 | TRPA1 antagonist | Probechem Biochemicals

Chemical Structure : LY3526318

LY3526318 (LY-3526318)

Catalog No.: PC-23622Not For Human Use, Lab Use Only.

LY3526318 is an orally bioavailable, potent, and selective TRPA1 antagonist with limited penetration to the central nervous system, effectively blocks cinnamaldehyde-evoked activation of rat and human TRPA1.

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Biological Activity

Physicochemical Properties

M.Wt	556.47
Formula	C23H19F3N10O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(3-methyl-1-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-(trifluoromethyl)pyrimidin-5-yl)pyridin-2-yl)propanamide

References

1. Bamps D, et al. Clin Pharmacol Ther. 2023 Nov;114(5):1093-1103.

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LY3526318 (LY-3526318)

Biological Activity

Physicochemical Properties

References

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