TRPM5 agonist 64

Chemical Structure : TRPM5 agonist 64

Catalog No.: PC-22256Not For Human Use, Lab Use Only.

TRPM5 agonist 64 is a potent, selective TRPM5 agonist with pEC50 of 7.8 and .1 for mTRPM5 and hTRPM5, respectively.

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Biological Activity

TRPM5 agonist 64 is a potent, selective TRPM5 agonist with pEC50 of 7.8 and .1 for mTRPM5 and hTRPM5, respectively.
TRPM5 agonist 64 shows high selectivity (>100-fold) over hTRPM8/hTRPV1/hTRPV4/hTRPA1/hTRPM4 (pEC50, <4.8/<4.8/<4.8/5.5/5.5).
TRPM5 agonist 64 shows a statistically significant increase of the fecal parameters after oral administration at 100 mg/kg.

Physicochemical Properties

M.Wt	316.22
Formula	C11H7Cl2N3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-N-[(5-chloro-2-thiazolyl)methyl]-1,2-benzisothiazol-6-amine

References

1. Alessio Barilli, et al. J Med Chem. 2021 May 13;64(9):5931-5955.

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TRPM5 agonist 64

Biological Activity

Physicochemical Properties

References

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