Catalog No.: PC-24809Not For Human Use, Lab Use Only.
AP-18 is a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with IC50 of 3.1 uM and 4.5 μM for human and mouse TRPA1 respectively.
AP-18 is a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with IC50 of 3.1 uM and 4.5 μM for human and mouse TRPA1 respectively. AP-18 shows no effect on TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide in CHO cells assayed by ratiometric Ca2+ imaging. AP-18 blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes. AP-18 reverses complete CFA-induced mechanical hyperalgesia in mice.
Physicochemical Properties
M.Wt
209.67
Formula
C11H12ClNO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime
References
1. Petrus M, et al. Mol Pain. 2007;3:40. Published 2007 Dec 17.
